Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate… Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19 available at https://www.nejm.org/doi/full/10.1056/nejmoa2019014need help to criticize this research studyI need help to find some answers from this given study:What do you notice as you read?Before you dive into the full study, consider what you already “know” or think you know about this topic. It was quite a hot topic in health care circles in 2020. Did you encounter any previous reading on this topic? What sources did you read? Be very honest with yourself here. Humans have strong tendencies towards bias and it is easy to believe you already know the “right” answers to questions without having done the academic work. Did you have friends or family asking you about these drugs? It might be helpful to jot down the “sum of your knowledge” on a sheet of paper before proceeding. Can you pull out the PICOT from this abstract?P:I: (hint: there are 3 groups – two interventional and one control. Your control group is the “C” of the PICOT)C:O: (hint: there is one primary outcome, and mention of at least one secondary outcome. List the primary here)T: What is the “n” for this study?The measurement tool used was a 7 point ordinal scale. What questions do you have about this?What was the p value for comparing the patients who took hydroxychloroquine versus standard care?What was the p value for comparing the patients who took the hydroxychloroquine-azithromycin combo versus standard care? Was either p value below 0.05? What does that mean?What else was noted about these two interventional groups?Read the introduction to the paper. What do the terms “in vivo” and “in vitro” mean?The authors reference two “small, nonrandomized” studies that preceded this one (3,4). Find them in the reference list. What can you tell about the studies based on their titles? Previous RCTs are also referenced (9-11). Look at these titles as well. What kinds of patients were included?What kinds of patients were excluded? Why do you suppose that is?Note informed consent. Health Science Science NursingMUS 455
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